Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (AA 61-95) antibody

Details for Product No. ABIN121176
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Antigen
Synonyms NACP, alphaSYN, PARK1, PARK4, PD1
Epitope
AA 61-95
(40), (34), (27), (25), (25), (14), (12), (9), (7), (7), (7), (6), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(383), (165), (141), (92), (89), (78), (24), (24), (3), (1), (1)
Host
Mouse
(281), (94), (15), (10), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (11), (11), (8), (8), (8), (8), (8), (8), (8), (8)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(267), (113), (82), (80), (74), (67), (29), (22), (16), (6), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN121176
412.50 $
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Immunogen Recombinant human a -synuclein (1-140) purified from E. coli
Clone 5C2
Isotype IgG1
Purification Affinity Chromatography on Protein G
Alternative Name Alpha-Synuclein / SNCA
Background A -synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a -synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A b component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain. Alternate Names: Synuclein-alpha, alpha-Synuclein, SNCA, MGC110988, NACP, PARK1, PARK4, PD1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor.
UniProt P37840
Research Area Neurology
Application Notes ELISA. Western blot (1:500 - 1:2,000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
General Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).

Paik, Lee, Kim et al.: "Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid." in: Archives of biochemistry and biophysics, Vol. 344, Issue 2, pp. 325-34, 1997 (PubMed).

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