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Details for Product No. ABIN121176

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (AA 61-95) antibody

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Antigen
Synonyms NACP, PARK1, PARK4, PD1
Epitope
»Alternatives AA 61-95
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN121176
Quantity 0.1 mL
Price
401.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant human a -synuclein (1-140) purified from E. coli
Clone 5C2
Isotype IgG1
Purification Affinity Chromatography on Protein G
Alternative Name Alpha-Synuclein / SNCA
Background A -synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a -synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A b component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain. Alternate Names: Synuclein-alpha, alpha-Synuclein, SNCA, MGC110988, NACP, PARK1, PARK4, PD1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor.
UniProt P37840
Research Area Neurology
Application Notes ELISA. Western blot (1:500 - 1:2,000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 0.09% Sodium Azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).

Paik, Lee, Kim et al.: "Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid." in: Archives of biochemistry and biophysics, Vol. 344, Issue 2, pp. 325-34, 1997 (PubMed).

Alternatives for antigen "Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)", type "Antibodies"
Hosts (252), (92), (16), (13), (1)
Reactivities (356), (171), (148), (91), (87), (78), (24), (24), (2), (1), (1), (1)
Applications (236), (134), (92), (80), (60), (49), (22), (17), (13), (8), (6), (3), (2), (1), (1), (1)
Conjugates (11), (9), (9), (8), (8), (8), (8), (8), (8), (8), (8)
Epitopes (36), (31), (25), (23), (20), (12), (9), (8), (7), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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