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Synuclein, alpha (SNCA) (AA 61-95) antibody

Details for Product No. ABIN121176, Supplier: Login to see
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
Epitope
AA 61-95
62
49
39
37
35
24
13
13
12
10
8
6
6
5
5
5
5
5
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
522
202
196
13
11
11
8
6
2
2
2
2
1
1
1
Host
Mouse
404
106
32
10
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
22
20
16
6
6
6
6
6
6
6
6
6
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
378
189
123
94
76
67
24
21
18
16
10
6
2
1
1
1
1
1
Supplier
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Immunogen Recombinant human a -synuclein (1-140) purified from E. coli
Clone 5C2
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein G
Alternative Name alpha-Synuclein / SNCA (SNCA Antibody Abstract)
Background Alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A beta component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
UniProt P37840
Research Area Neurology
Pathways
Application Notes ELISA. Western blot (1:500 - 1:2,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Paik, Lee, Kim et al.: "Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid." in: Archives of biochemistry and biophysics, Vol. 344, Issue 2, pp. 325-34, 1997 (PubMed).

Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).