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Details for Product No. ABIN121893

Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) (C-Term) antibody

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Antigen
Synonyms CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, Mch3, mCASP-7, AI314680, ICE-IAP3, caspase-7, xCaspase-7, caspase7, cmh-1, ice-lap3, mch3, CASP7
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN121893
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen A 16 amino acid peptide from human Caspase-7 carboxy-terminus
Isotype IgG
Purification Affinity Chromatography
Alternative Name Caspase-7
Background ICE-LAP3 is a member of the ICE/Ced-3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase-7 occurs during cell death induced by the cytokine death receptors Fas/APO-1 and the receptor of tumour necrosis factor (TNFR-1), coupled with the fact that granzyme-B activated Caspase-7 cleaves the nuclear enzyme poly (ADPribose) polymerase (PARP), suggests an important role for Caspase-7 in both cytokine-mediated and Granzyme-B mediated apoptosis pathways. Alternate Names: CASP7, Mch-3, ICE-LAP3, CMH-1, MCH3, Caspase 7, CASP 7, ICE-like apoptotic protease 3, ICE- LAP3, Apoptotic protease Mch-3, apoptosis-related cysteine protease, ICELAP3, CMH1.
UniProt P55210
Research Area Apoptosis/Necrosis
Application Notes Western Blot: 1.0ug/ml - 2.0ug/ml. Immunohistochemistry on paraffin sections: 2.0ug/ml, this product does not require protein digestion pre-treatment of paraffin sections eg. Trypsin or pronase prior to staing, this product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Skeletal muscle tissue. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Duan, Chinnaiyan, Hudson et al.: "ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis." in: The Journal of biological chemistry, Vol. 271, Issue 3, pp. 1621-5, 1996 (PubMed).

Juan, McNiece, Argento et al.: "Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3." in: Genomics, Vol. 40, Issue 1, pp. 86-93, 1997 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Alternatives for antigen "Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7)", type "Antibodies"
Hosts (128), (48), (3)
Reactivities (166), (82), (70), (29), (24), (16), (12), (7), (5), (5), (4), (2), (1)
Applications (152), (53), (49), (41), (23), (20), (7), (6), (4), (4), (3), (2), (1), (1), (1)
Conjugates (7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (21), (16), (9), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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