CRHR1 antibody (N-Term)

Catalog No. ABIN122552

The Rabbit Polyclonal anti-CRHR1 antibody is suitable to detect CRHR1 in samples from Human, Mouse and Rat. It has been validated for IHC (p).

Quick Overview for CRHR1 antibody (N-Term) (ABIN122552)

Target: CRHR1 (Corticotropin Releasing Hormone Receptor 1 (CRHR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRHR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CRHR1 Antibody

Binding Specificity: N-Term

Specificity: Reacts to Corticotropin-Releasing Factor Receptor 1 (Family: GPCR, subfamily Corticotropin releasing factor).

Purification: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugated.

Application Details

Application Notes: Immunohistochemistry on paraffin embedded sections: 13 μg/mL Antigen Retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.7, containing 0.01 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CRHR1

Target: CRHR1 (Corticotropin Releasing Hormone Receptor 1 (CRHR1))

Alternative Name: CRHR1

Background: Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries. Ligand: Corticotropin-releasing factor (CRF)Synonyms: CRF-R, CRF1, CRFR, CRFR1, CRH-R 1, CRHR, CRHR-1, Corticotropin-releasing factor receptor 1, Corticotropin-releasing hormone receptor 1

Gene ID: 1394

UniProt: P34998

Pathways: Hormone Transport, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Feeding Behaviour, Negative Regulation of Transporter Activity