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Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibody

Antigen

Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)
Synonyms MCH2, Mch2, mCASP-6, MGC93335, xCaspase-6, mch2, caspase-6, CASP6, MGC127633, zgc:112960, casp6
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
2 references available
Catalog no. ABIN127030
Quantity 0.1 mg  (0.5 mg/ml)  (Variants)
Price 484.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days

Additional Information
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Alternative name Caspase-6
UniProt P55212
Immunogen Synthetic peptide surrounding amino acids mapping to the Cterminus of the large fragmentof human caspase-6.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Description Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that isprocessed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of themajor caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly(ADP-ribose) polymerase (PARP) and nuclear lamin A.
Characteristics Synonyms: CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2

Application Details
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Application Notes Western Blot: 0.5-4 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
Purification Affinity Purified
Buffer PBS, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Storage Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Research Area Apoptosis/Necrosis
Restrictions For Research Use only

Publications
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Faleiro, Kobayashi, Fearnhead et al.: "Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells." in: The EMBO journal, Vol. 16, Issue 9, pp. 2271-81, 1997 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)", type "Antibodies"
Hosts Rabbit (75), Mouse (13)
Reactivities Human (76), Rat (Rattus) (24), Mouse (Murine) (20), Cow (Bovine) (5), Dog (Canine) (4), Cat (Feline) (1), Chicken (1), Hamster (1), Monkey (1), Pig (Porcine) (1), Rabbit (1), Sheep (Ovine) (1)
Applications Western Blotting (WB) (77), ELISA (38), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (26), Immunohistochemistry (IHC) (21), Immunofluorescence (IF) (15), Immunoprecipitation (IP) (12), Immunocytochemistry (ICC) (8), Flow Cytometry (FACS) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), FITC (1), PE,Cy5.5 (1)
Epitopes C-Term (10), N-Term (8), pSer257 (8), Internal Region (4), Cleaved-Asp162 (2), Ser257 (2), AA 250-264 (1), C-Term,active (1), Center (1), Cleavage Site (1), Middle Region (1), Pro-form (1), Prodomain (1), active (1), cleaved (1), pSer146 (1)