BCL2-Like 1 (BCL2L1) antibody (RPE)

Details for Product No. ABIN135024
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Antigen
Synonyms
bcl-XL, bcl-x, bcl-x(l), bcl-xl/s, bcl-xs, bcl2l, bclx, bclxl, xR11, BCL2L1, Bcl-xS, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, Bcl-xl,  ... show more
bcl-XL, bcl-x, bcl-x(l), bcl-xl/s, bcl-xs, bcl2l, bclx, bclxl, xR11, BCL2L1, Bcl-xS, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, Bcl-xl, Bclx, bcl-X, BCL-XL, Bcl-xL, bcl-xl show less
Reactivity
Human
(276), (162), (138), (40), (40), (39), (12), (4), (3), (2), (1), (1)
Host
Mouse
(218), (82), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
RPE
(14), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC)
(211), (94), (92), (63), (46), (40), (37), (34), (19), (15), (2), (2), (1)
Pubmed 8 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN135024
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Immunogen Recombinant Bcl-xS Ig
Clone 7B2-5
Isotype IgG
Characteristics The antibody detects: Human Bcl-xL (Mr 29 kDa)
Mab 7B2.5 recognizes both human and rodent Bcl-xL.
Alternative Name Bcl-xL
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.
Research Area Cancer
Application Notes Working Dilution:
FACS: 03 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.1 mg in 1.0 mL of PBS / NaN3 and a stabilizing agent.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze!
Protect conjugated products from light.

Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Supplier Images
anti-BCL2-Like 1 (BCL2L1) antibody (RPE) anti-BCL2-Like 1 (BCL2L1) antibody (RPE)
Product cited in: Urbanska, Lanitis, Poussin et al.: "A universal strategy for adoptive immunotherapy of cancer through use of a novel T cell antigen receptor." in: Cancer research, 2012 (PubMed).

General Cohen: "Programmed cell death in the immune system." in: Advances in immunology, Vol. 50, pp. 55-85, 1991 (PubMed).

Chittenden, Harrington, OConnor et al.: "Induction of apoptosis by the Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).

Kiefer, Brauer, Powers et al.: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).

Yin, Oltvai, Korsmeyer: "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax." in: Nature, Vol. 369, Issue 6478, pp. 321-3, 1994 (PubMed).

Cheng, Levine, Boise et al.: "Bax-independent inhibition of apoptosis by Bcl-XL." in: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).

Rajah, Bhala, Nunn et al.: "7S nerve growth factor is an insulin-like growth factor-binding protein protease." in: Endocrinology, Vol. 137, Issue 7, pp. 2676-82, 1996 (PubMed).

Gottschalk, Boise, Oltvai et al.: "The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated." in: Cell death and differentiation, Vol. 3, Issue 1, pp. 113-8, 2006 (PubMed).

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