BCL2-Like 1 (BCL2L1) (N-Term), (AA 3-14) antibody

Details for Product No. ABIN135025
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Antigen
Synonyms
bcl-XL, bcl-x, bcl-x(l), bcl-xl/s, bcl-xs, bcl2l, bclx, bclxl, xR11, BCL2L1, Bcl-xS, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, Bcl-xl,  ... show more
bcl-XL, bcl-x, bcl-x(l), bcl-xl/s, bcl-xs, bcl2l, bclx, bclxl, xR11, BCL2L1, Bcl-xS, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, Bcl-xl, Bclx, bcl-X, BCL-XL, Bcl-xL, bcl-xl show less
Epitope
N-Term, AA 3-14
(33), (31), (22), (21), (11), (9), (8), (7), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(296), (170), (145), (43), (43), (42), (12), (6), (4), (3), (1), (1)
Host
Mouse
(235), (88), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(14), (8), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(226), (102), (99), (68), (53), (42), (40), (38), (22), (16), (15), (4), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN135025
236.50 $
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Immunogen KLH-conjugated peptide corresponding to AA 3-14 near the N-terminus mouse and human Bcl-xL1 Ig
Clone 2H12
Isotype IgG2a
Characteristics The antibody detects: Mouse and human Bcl-xL (Mr 29 kDa)
Purification Purified
Alternative Name Bcl-xL
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.
Research Area Cancer
Application Notes Working Dilution:
Immunohistochemistry: 5-10 µg/mL
Western Blotting: 1 µg/mL
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
Preservative Without preservative
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
General Chittenden, Harrington, OConnor et al.: "Induction of apoptosis by the Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).

Kiefer, Brauer, Powers et al.: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).

Boise, González-García, Postema et al.: "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." in: Cell, Vol. 74, Issue 4, pp. 597-608, 1993 (PubMed).

Hsu, Wolter, Youle: "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3668-72, 1997 (PubMed).

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