Integrin alpha M (ITGAM) antibody

Details for Product No. ABIN135134
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Antigen
Synonyms CD11b/CD18, CR3, CR3A, Cd11b, F730045J24Rik, Ly-40, MAC1, Mac-1, Mac-1a, CD11B, MAC-1, MAC1A, MO1A, SLEB6, C3bi
Reactivity
Mouse (Murine)
(337), (266), (65), (22), (16), (13), (13), (7), (6), (3), (2), (1), (1)
Host
Rat
(268), (235), (55), (7), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(95), (60), (50), (26), (17), (11), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunoprecipitation (IP)
(454), (117), (115), (71), (62), (41), (37), (35), (34), (33), (10), (6), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.5 mg
Options
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Request Want additional data for this product?

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Catalog No. ABIN135134
291.50 $
Plus shipping costs $45.00 and if applicable $26.40 dry ice

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice1
Clone 3A33
Isotype IgG2a
Characteristics The antibody detects: M subunit (Mr 170 kDa) of the CD11b/CD18 heterodimer
Endotoxin Level Low Endotoxin
Alternative Name CD11b/Mac-1a
Background CD11b (integrin M subunit) combines with CD18 (integrin 2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.
Application Notes Working Dilution:
FACS: 1 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS.
Preservative Azide free
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage -20 °C
Storage Comment Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.
General Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." in: Cell, Vol. 76, Issue 2, pp. 301-14, 1994 (PubMed).

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