Transferrin Receptor antibody

Catalog No. ABIN135263

The Rat Monoclonal anti-Transferrin Receptor antibody is suitable to detect Transferrin Receptor in samples from Mouse. It has been validated for FACS, WB, IP, ICC, BR, DD and Sep.

Quick Overview for Transferrin Receptor antibody (ABIN135263)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Blocking Reagent (BR), Drug Delivery (DD), Separation (Sep)

Clone: RI7217

Product Details anti-Transferrin Receptor Antibody

Purpose: Rat Anti-Mouse CD71-LE/AF

Specificity: Mouse CD71, Mr 95 kDa

Characteristics: Low Endotoxin/Azide Free Anti-Mouse CD71 antibody for use in flow cytometry, immunocytochemistry, western blotting, immunoprecipitation, blocking, separation, and drug delivery assays.

Endotoxin Level: Low Endotoxin

Immunogen: DMSO induced Friend erythroleukemia 745.6

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: 2-8°C

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: CD71

Background: CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor chain.

Gene ID: 22042

UniProt: Q62351

Pathways: Transition Metal Ion Homeostasis