NCAM2 antibody (AA 51-150) (Alexa Fluor 350)

Catalog No. ABIN1389231

Product Details anti-NCAM2 Antibody (Alexa Fluor 350)

Target: NCAM2 (Neural Cell Adhesion Molecule 2 (NCAM2))

Binding Specificity: AA 51-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCAM2 antibody is conjugated to Alexa Fluor 350

Application: Flow Cytometry (FACS)

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NCAM2

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NCAM2

Target: NCAM2 (Neural Cell Adhesion Molecule 2 (NCAM2))

Alternative Name: NCAM2 (NCAM2 Products)

Synonyms: NCAM21 antibody, Ncam-2 antibody, Ocam antibody, RNCAM antibody, zOCAM antibody, OCAM-GPI antibody, NCAM2 antibody, ncam21 antibody, neural cell adhesion molecule 2 antibody, zgc:152904 antibody, NCAM2 antibody, Ncam2 antibody, ncam2 antibody, LOC100471034 antibody, zgc:152904 antibody

Background:

Synonyms: N CAM 2, N CAM 21, N CAM2, N CAM21, N-CAM-2, NCAM 2, NCAM 21, NCAM-2, Ncam2, NCAM2_HUMAN, NCAM21, Neural cell adhesion molecule 2, OCAM GPI, R4B12, RB 8 neural cell adhesion molecule, RB8 neural cell adhesion molecule, RNCAM.

Background: NCAM2 is an 837 amino acid protein encoded by the human gene NCAM2. NCAM2 contains five immunoglobulin-like domains, two Fibronectin type III domains, a transmembrane domain and a cytoplasmic domain. The gene is expressed most strongly in human adult and fetal brain. NCAM2 is a member of the neural cell adhesion molecule (NCAM) family. NCAMs are closely related cell surface glycoproteins involved in cell to cell interactions during growth and are thought to play an important role in embryogenesis and development. NCAM2 is a considered a good candidate for involvement in certain Down syndrome phenotypes because a slight overexpression of NCAMs increases many-fold the homotypic adhesion properties of cells. Stat5 regulates NCAM2 in vivo by binding to the NCAM2 intron in the NKL natural killer cell line, this binding is induced by cytokines that activate Stat5. Neither Stat1 nor Stat3 bind to this region, despite sharing a consensus binding sequence with Stat5.