DMPK antibody (AA 51-120) (Alexa Fluor 350)

Catalog No. ABIN1393053

Product Details anti-DMPK Antibody (Alexa Fluor 350)

Target: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Binding Specificity: AA 51-120

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMPK antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DMPK

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DMPK

Target: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Alternative Name: DMPK (DMPK Products)

Synonyms: DMPK antibody, DM antibody, DM1 antibody, DM1PK antibody, DMK antibody, MDPK antibody, MT-PK antibody, Dm15 antibody, DM1 protein kinase antibody, dystrophia myotonica-protein kinase antibody, DMPK antibody, Dmpk antibody

Background:

Synonyms: Dystrophia myotonica protein kinase, DM 1, DM, DM kinase, DM protein kinase, DM-kinase, DM1, DM1 protein kinase, DM1PK, DMK, DMPK, DMPK_HUMAN, Dystrophia myotonica 1, Dystrophia myotonica protein kinase, MDPK, MT PK, MT-PK, Myotonic dystrophy associated protein kinase, Myotonic dystrophy protein kinase, Myotonin protein kinase A, Myotonin protein kinase, Myotonin-protein kinase, Thymopoietin homolog.

Background: Myotonic dystrophy protein kinase is a multi-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis (1). DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction (2,3). DM arises through expansion of CTG repeats in the 3?-UTR of the DMPK gene (4). Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus (5). These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype (6). Other substrates for DMPK include myogenin, L-type calcium channels, and Phospholemman (PLM) (1).

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development