LAMa4 antibody (AA 901-1000) (HRP)

Catalog No. ABIN1406894

Product Details anti-LAMa4 Antibody (HRP)

Target: LAMa4 (Laminin, alpha 4 (LAMa4))

Binding Specificity: AA 901-1000

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMa4 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Laminin alpha 4

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LAMa4

Target: LAMa4 (Laminin, alpha 4 (LAMa4))

Alternative Name: Laminin alpha 4 (LAMa4 Products)

Synonyms: si:dkey-119m7.3 antibody, si:busm1-189a20.2 antibody, CMD1JJ antibody, LAMA3 antibody, LAMA4*-1 antibody, RGD1560062 antibody, laminin subunit alpha 4 antibody, laminin, alpha 4 antibody, LAMA4 antibody, lama4 antibody, Lama4 antibody

Background:

Synonyms: LAMA3, LAMA4 1, LAMA4, LAMA4_HUMAN, Laminin alpha 4, Laminin alpha 4 chain, Laminin subunit alpha 4 precursor, Laminin subunit alpha-4, Laminin-14 subunit alpha, Laminin-8 subunit alpha, Laminin-9 subunit alpha.

Background: Laminins are essential and abundant structural non-collagenous glyco- proteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of laminins with stabilizing Type IV collagen networks, Nidogen, and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve, and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each laminin is a heterotrimer of a, b, and g chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and cognate laminin receptors. The human Laminin a-4 gene maps to chromosome 6q21 and is expressed in adult heart, lung, ovary, small and large intestines, liver, and placenta.

Pathways: Brown Fat Cell Differentiation