AP5Z1 antibody (AA 288-370) (HRP)

Catalog No. ABIN1411052

Product Details anti-AP5Z1 Antibody (HRP)

Target: AP5Z1 (Adaptor-Related Protein Complex 5, zeta 1 Subunit (AP5Z1))

Binding Specificity: AA 288-370

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AP5Z1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SPG48

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AP5Z1

Target: AP5Z1 (Adaptor-Related Protein Complex 5, zeta 1 Subunit (AP5Z1))

Alternative Name: SPG48 (AP5Z1 Products)

Synonyms: KIAA0415 antibody, SPG48 antibody, zeta antibody, C330006K01Rik antibody, adaptor related protein complex 5 zeta 1 subunit antibody, adaptor-related protein complex 5, zeta 1 subunit antibody, AP5Z1 antibody, Ap5z1 antibody

Background:

Synonyms: Hypothetical protein LOC9907, KIAA0415, Uncharacterized protein KIAA0415, AP5Z1_HUMAN.

Background: Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5 % of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. KIAA0415 is a 807 amino acid protein that exists as three alternatively spliced isoforms. The KIAA0415 gene product has been provisionally designated KIAA0415 pending further characterization.