IPO7 antibody (AA 365-460) (HRP)

Catalog No. ABIN1417780

Product Details anti-IPO7 Antibody (HRP)

Target: IPO7 (Importin 7 (IPO7))

Binding Specificity: AA 365-460

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IPO7 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RanBP7/Importin 7

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IPO7

Target: IPO7 (Importin 7 (IPO7))

Alternative Name: RanBP7 (IPO7 Products)

Synonyms: fb33d09 antibody, wu:fb33d09 antibody, zgc:66425 antibody, zgc:76878 antibody, imp7 antibody, ranbp7 antibody, Imp7 antibody, RANBP7 antibody, A330055O14Rik antibody, C330016G14 antibody, Ranbp7 antibody, importin 7 antibody, importin 7 S homeolog antibody, importin-7 antibody, karyopherin antibody, ipo7 antibody, ipo7.S antibody, IPO7 antibody, CpipJ_CPIJ002096 antibody, PTRG_08544 antibody, SJAG_03693 antibody, NAEGRDRAFT_71372 antibody, VDBG_01971 antibody, MGYG_08162 antibody, Tsp_01943 antibody, Tsp_01946 antibody, Ipo7 antibody

Background:

Synonyms: Imp 7, Imp7, Importin-7, Importin7, IPO 7, IPO7, IPO7_HUMAN, Ran binding protein 7, Ran-binding protein 7, RANBP 7, RanBP7.

Background: Importin 7 is a 1,038 amino acid protein encoded by the human gene IPO7. Importin-7 belongs to the importin b family and contains one importin N-terminal domain. Importin-7 functions in nuclear protein import, either by acting as an autonomous nuclear transport receptor or as an adapter-like protein in association with the Importin b subunit KPNB1. Acting autonomously, Importin-7 is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to Importin-7, the Importin-7/substrate complex dissociates and Importin-7 is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Importin-7 is a nuclear protein that is expressed in most tissues.

Pathways: Protein targeting to Nucleus