SMARCD3 antibody (HRP)

Catalog No. ABIN1420828

Product Details anti-SMARCD3 Antibody (HRP)

Target: SMARCD3 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 (SMARCD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCD3 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SMARCD3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SMARCD3

Target: SMARCD3 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 (SMARCD3))

Alternative Name: SMARCD3 (SMARCD3 Products)

Synonyms: SMARCD3 antibody, baf60c antibody, cracd3 antibody, rsc6p antibody, BAF60C antibody, CRACD3 antibody, Rsc6p antibody, 1500001J14Rik antibody, 2210409C08Rik antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 S homeolog antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b antibody, SMARCD3 antibody, smarcd3.S antibody, Smarcd3 antibody, smarcd3b antibody

Background:

Synonyms: 60 kDa BRG 1/Brm associated factor subunit C, 60 kDa BRG-1/Brm-associated factor subunit C, BAF60C, BRG1 associated factor 60C, BRG1-associated factor 60C, CRACD3, MGC111010, Rsc6p, Smarcd3, SMRD3_HUMAN, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3.

Background: SMARCD3, is a member of the SMARCD family and contains one SWIB domain. Two isoforms, isoform 1 and isoform 2 exist due to alternative splicing events. Both isoforms are expressed in placenta, salivary gland, kidney, brain, trachea, uterus, prostate, testis, thyroid, spleen and heart, while isoform 1 is also expressed in adipose tissue and skeletal muscle. Localizing to the nucleus, SMARCD3 is a component of the ATP-dependent chromatin remodeling complex SNF/SWI and is believed to play a role in nucleosome remodeling. SMARCD3 also plays an important role in the regulation of muscle development. In mice, the silencing of the gene en-coding SMARCD3 leads to defects in heart morphogenesis. In addition, both isoforms of SMARCD3 directly interact with and function as coactivators for several transcription factors.

Gene ID: 6604

Pathways: Regulation of Lipid Metabolism by PPARalpha