CD46 antibody (FITC)

Catalog No. ABIN1449264

Product Details anti-CD46 Antibody (FITC)

Target: CD46

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Purification: Protein A agarose

Immunogen: Human pancreatic carcinoma cell line (AsPC1)

Clone: TGP3

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS containing 1 % BSA and 0.09 % NaN3

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for CD46

Target: CD46

Alternative Name: CD46 / MCP (CD46 Products)

Background: CD46, also known as membrane cofactor protein (MCP), was first described as a membrane complement regulator that fu nctions as a cofactor with factor I to cleave complement factors C3b and C4b and thereby protect the cell from co mplement attack. In humans, CD46 is expressed on all nuc leated cells. In the rodent animals, its expression is limited only in testis, indicating that the major function of CD46 among different species lies in fertilization. CD46 and other membrane complement regulatory proteins (CD55 and CD59) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. Several pathogens, including viruses and bacteria (measles virus, human herpesvirus 6, human group B and D adenoviruses, Streptococcus pyogenes , and pathogenic Neisseria species) have been reported to use CD46 for invasion. Recent evidence also indicates that CD 46 signaling events play an important role in linking innate and acquired immune function.Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen

Gene ID: 9606

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization