AKTIP antibody (Middle Region)
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- Target See all AKTIP Antibodies
- AKTIP (AKT Interacting Protein (AKTIP))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Chicken, Xenopus laevis
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AKTIP antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA
- Cross-Reactivity (Details)
- Species reactivity (expected):Mouse, Rat, Chicken, Dog, African clawed frog, ZebrafishSpecies reactivity (tested):Human
- Purification
- Purified using peptide immunoaffinity column
- Immunogen
- Synthetic peptide directed towards the middle region of human AKTIP
- Top Product
- Discover our top product AKTIP Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- Add 50 μL of distilled water to a final concentration of 1 mg/mL.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
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- Target
- AKTIP (AKT Interacting Protein (AKTIP))
- Alternative Name
- AKTIP / FTS (AKTIP Products)
- Synonyms
- FT1 antibody, FTS antibody, cb798 antibody, fts antibody, zgc:77699 antibody, fts-A antibody, aktip antibody, fts-B antibody, MGC133931 antibody, AL023020 antibody, Fif antibody, Ft antibody, Ft1 antibody, Fts antibody, AKT interacting protein antibody, akt interacting protein antibody, AKT interacting protein L homeolog antibody, AKT interacting protein S homeolog antibody, thymoma viral proto-oncogene 1 interacting protein antibody, AKTIP antibody, aktip antibody, aktip.L antibody, aktip.S antibody, Aktip antibody
- Background
- AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.Synonyms: AKT-interacting protein, FT1, Fused toes protein homolog
- Gene ID
- 64400
- NCBI Accession
- NP_001012398
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