Chromodomain Helicase DNA Binding Protein 7 (CHD7) (N-Term) antibody

Details for Product No. ABIN1450043
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Antigen
Synonyms
CHD7, fd19h06, si:ch211-197o6.2, wu:cegs2051, wu:fb37f10, wu:fb39h04, wu:fd19h06, HH5, IS3, KAL5, A730019I05Rik, Cycn, Cyn, Dz, Edy, Flo, GENA 47, GENA 60, Gena 52, Lda, Mt, Obt, Todo, WBE1, Whi, meti ... show more
CHD7, fd19h06, si:ch211-197o6.2, wu:cegs2051, wu:fb37f10, wu:fb39h04, wu:fd19h06, HH5, IS3, KAL5, A730019I05Rik, Cycn, Cyn, Dz, Edy, Flo, GENA 47, GENA 60, Gena 52, Lda, Mt, Obt, Todo, WBE1, Whi, metis show less
Epitope
N-Term
(7), (4), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(16), (7), (2)
Host
Rabbit
(10), (6), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(11), (10), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1450043
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Immunogen CHD7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CHD7
Isotype IgG
Specificity Multiple isoforms of CHD7 are known to exist.
Purification Affinity chromatography purified via peptide column
Alternative Name CHD7
Background CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.
Alternate names: ATP-dependent helicase CHD7, CHD-7, Chromodomain-helicase-DNA-binding protein 7, KIAA1416
Gene ID 55636
UniProt Q9P2D1
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Woodage, Basrai, Baxevanis et al.: "Characterization of the CHD family of proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 21, pp. 11472-7, 1997 (PubMed).

Cavalli, Paro: "Chromo-domain proteins: linking chromatin structure to epigenetic regulation." in: Current opinion in cell biology, Vol. 10, Issue 3, pp. 354-60, 1998 (PubMed).

Vissers, van Ravenswaaij, Admiraal et al.: "Mutations in a new member of the chromodomain gene family cause CHARGE syndrome." in: Nature genetics, Vol. 36, Issue 9, pp. 955-7, 2004 (PubMed).

Schnetz, Handoko, Akhtar-Zaidi et al.: "CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001023, 2010 (PubMed).

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