UHRF1 Binding Protein 1-Like (UHRF1BP1L) (Middle Region) antibody

Details for Product No. ABIN1450050
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Antigen
Synonyms MGC80013, UHRF1BP1L, si:dkeyp-90a8.1, 2010319N22Rik, 4930506D01Rik, AA589495, C80672, E030041M21Rik, mKIAA0701, SHIP164
Epitope
Middle Region
(8), (5), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(19), (5)
Host
Rabbit
(17), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(19), (14), (2), (2), (2)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN1450050
401.50 $
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Immunogen 17 amino acid synthetic peptide near the center of Human UHRF1BP1L
Isotype IgG
Specificity This antibody will recognize both isoforms (at least two isoforms of UHRF1BP1L are known to exist). This UHRF1BP1L antibody is predicted not to cross-react with UHRF1BP1
Purification Affinity chromatography purified via peptide column
Alternative Name UHRF1BP1L
Background The Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1-like (UHRF1BP1L) is closely related to UHRF1BP1, also known as ICBP90, a transcription and cell cycle regulator that specifically binds to the histone H3 N-terminal tail. While little is known of UHRF1BP1L, UHRF1BP1 is required for proper heterochromatin formation in mammalian cells. Furthermore, UHRF1BP1 is thought to be a pivotal target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells, suggesting that UHRF1BP1L may also be involved in chromatin regulation and cell proliferation.
Alternate names: KIAA0701, UHRF1-binding protein 1-like
Gene ID 23074
NCBI Accession NP_055869
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hopfner, Mousli, Jeltsch et al.: "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression." in: Cancer research, Vol. 60, Issue 1, pp. 121-8, 2000 (PubMed).

Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, 2004 (PubMed).

Karagianni, Amazit, Qin et al.: "ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation." in: Molecular and cellular biology, Vol. 28, Issue 2, pp. 705-17, 2008 (PubMed).

Fang, Xing, Bronner et al.: "ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells." in: Cellular immunology, Vol. 257, Issue 1-2, pp. 80-7, 2009 (PubMed).

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