TSHZ3 antibody (N-Term)

Catalog No. ABIN1450132

This Rabbit Polyclonal antibody specifically detects TSHZ3 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TSHZ3 antibody (N-Term) (ABIN1450132)

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSHZ3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TSHZ3 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the amino terminus of human TSHZ3 / ZNF537

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TSHZ3

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Alternative Name: TSHZ3 / ZNF537

Background: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Both TSHZ3 and TSHZ1 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4. Recent experiments have also suggested this family of proteins may be involved in carcinogenesis.Synonyms: KIAA1474, TSH3, Teashirt homolog 3, Zinc finger protein 537

Gene ID: 57616

NCBI Accession: NP_065907

Pathways: Regulation of Muscle Cell Differentiation