TSHZ3 antibody

Catalog No. ABIN7231940

The Rabbit Polyclonal anti-TSHZ3 antibody (ABIN7231940) specifically detects TSHZ3 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TSHZ3 antibody (ABIN7231940)

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSHZ3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TSHZ3 Antibody

Purpose: Rabbit Anti-TSH3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of TSH3 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human TSH3 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TSHZ3

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Alternative Name: TSH3

Background: Teashirt homolog 3, Zinc finger protein 537TSHZ3 (Teashirt Zinc Finger Homeobox 3) encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which TSHZ3 has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of TSHZ3 and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. TSHZ3 is a Protein Coding gene. Diseases associated with TSHZ3 include Hydronephrosis and Endemic Goiter.

Molecular Weight: 118kD

Gene ID: 57616

UniProt: Q63HK5

Pathways: Regulation of Muscle Cell Differentiation