ENC1 antibody (C-Term)

Catalog No. ABIN1537267

Product Details anti-ENC1 Antibody

Target: ENC1 (Ectodermal-Neural Cortex 1 (With BTB-Like Domain) (ENC1))

Binding Specificity: AA 395-423, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ENC1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ENC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-423 amino acids from the C-terminal region of human ENC1.

Clone: RB37065

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: ENC1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for ENC1

Target: ENC1 (Ectodermal-Neural Cortex 1 (With BTB-Like Domain) (ENC1))

Alternative Name: ENC1 (ENC1 Products)

Synonyms: ENC1 antibody, LOC559101 antibody, CCL28 antibody, ENC-1 antibody, KLHL35 antibody, KLHL37 antibody, NRPB antibody, PIG10 antibody, TP53I10 antibody, Xencr-3 antibody, enc-1 antibody, encr-3 antibody, Nrpb antibody, ectodermal-neural cortex 1 antibody, ectodermal-neural cortex 1 (with BTB domain) L homeolog antibody, ENC1 antibody, enc1 antibody, enc1.L antibody, Enc1 antibody

Background: DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53, MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50 % of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.

Molecular Weight: 66130

Gene ID: 8507

NCBI Accession: NP_001243503, NP_001243504, NP_001243505, NP_003624

UniProt: O14682