ATP2C1 antibody
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- Target See all ATP2C1 Antibodies
- ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))
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Reactivity
- Human, Monkey
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ATP2C1 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of ATP2C1 expressed in E. coli.
- Clone
- 4G12
- Isotype
- IgG1
- Top Product
- Discover our top product ATP2C1 Primary Antibody
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." in: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).
: "ATP2C1 gene mutation analysis in Italian patients with Hailey-Hailey disease." in: The Journal of investigative dermatology, Vol. 125, Issue 5, pp. 933-5, (2005) (PubMed).
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Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." in: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).
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- Target
- ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))
- Alternative Name
- ATP2C1 (ATP2C1 Products)
- Synonyms
- ATP2C1 antibody, ATP2C1A antibody, BCPM antibody, HHD antibody, PMR1 antibody, SPCA1 antibody, hSPCA1 antibody, Spca1 antibody, si:dkey-11p23.6 antibody, SPCA antibody, 1700121J11Rik antibody, AW061228 antibody, D930003G21Rik antibody, pmr1 antibody, ATPase secretory pathway Ca2+ transporting 1 antibody, ATPase, Ca++ transporting, type 2C, member 1 antibody, ATPase, Ca++-sequestering antibody, ATP2C1 antibody, atp2c1 antibody, Atp2c1 antibody
- Background
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Description: ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
Aliases: HHD, BCPM, PMR1, SPCA1
- Molecular Weight
- 100 kDa
- Gene ID
- 27032
- HGNC
- 27032
- Pathways
- Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process
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