IL-2 antibody

Catalog No. ABIN182113

This Rabbit Polyclonal antibody specifically detects IL-2 in WB and EIA. It exhibits reactivity toward Sheep.

Quick Overview for IL-2 antibody (ABIN182113)

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Reactivity: Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-IL-2 Antibody

Specificity: Recognises ovine interleukin-2 (IL-2). No cross-reactivity is seen with ovine IL-1b, IL-6, IL-8, MCP-1 or TNF alpha.

Purification: None

Immunogen: Recombinant ovine IL-2

Application Details

Application Notes: Western blot. ELISA (1/500 detection, use ABIN119103 as coating antibody, It is recommended that ABIN182113 and any detection reagent are diluted in 10 % normal mouse serum prior to use in ELISA).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Serum stabilized by PBS and 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C or at -20 °C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: One year from despatch.

Expiry Date: 12 months

Target Details for IL-2

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Alternative Name: Interleukin-2 / IL2

Background: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.Synonyms: IL-2, T-cell growth factor, TCGF

Gene ID: 443401

UniProt: P19114

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation