CREB3L2 antibody (N-Term)

Catalog No. ABIN183063

Cited in 4+ publications. The Rabbit Polyclonal anti-CREB3L2 antibody (ABIN183063) specifically detects CREB3L2 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse and Rabbit samples.

Quick Overview for CREB3L2 antibody (N-Term) (ABIN183063)

Target: CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB3L2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CREB3L2 Antibody

Binding Specificity: N-Term

Purpose: CREB3L2 Antibody - N-terminal region

Sequence: HSYSLCEEPR AQSPFTHITS DSFNDDEVES EKWYLSTDF

Predicted Reactivity: Cow: 93%, Dog: 85%, Guinea Pig: 87%, Horse: 87%, Human: 100%, Mouse: 86%, Rabbit: 87%, Rat: 87%

Characteristics: This is a rabbit polyclonal antibody against CREB3L2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CREB3L2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34673-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CREB3L2 antibody (ABIN183063)

Lynch, Maillet, Vanhoutte, Schloemer, Sargent, Blair, Lynch, Okada, Aronow, Osinska, Prywes, Lorenz, Mori, Lawler, Robbins, Molkentin: "A thrombospondin-dependent pathway for a protective ER stress response." in: Cell, Vol. 149, Issue 6, pp. 1257-68, (2012) (PubMed).

Fox, Hanlon, Andrew: "The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity." in: The Journal of cell biology, Vol. 191, Issue 3, pp. 479-92, (2010) (PubMed).

Sievert, Jackson, Gai, Hakonarson, Judkins, Resnick, Sutton, Storm, Shaikh, Biegel: "Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene." in: Brain pathology (Zurich, Switzerland), Vol. 19, Issue 3, pp. 449-58, (2009) (PubMed).

Storlazzi, Mertens, Nascimento, Isaksson, Wejde, Brosjo, Mandahl, Panagopoulos: "Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma." in: Human molecular genetics, Vol. 12, Issue 18, pp. 2349-58, (2003) (PubMed).

Target Details for CREB3L2

Target: CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))

Alternative Name: CREB3L2

Background:

Background Information: CREB3L2 is a member of the old astrocyte specifically induced substance (OASIS) DNA binding and basic leucine zipper dimerization (bZIP) family of transcription factors, which includes CREB3 (MIM 606443) and CREB4 (MIM 607138).

Gene Name: CAMP responsive element binding protein 3-like 2

Alternative Symbols: BBF2H7

Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 2

Molecular Weight: 57 kDa

Gene ID: 64764

NCBI Accession: NP_919047

UniProt: Q70SY1

Pathways: Thyroid Hormone Synthesis