CREB3L2 antibody (Internal Region)

Catalog No. ABIN6257984

Product Details anti-CREB3L2 Antibody

Target: CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB3L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CREB3L2 Antibody detects endogenous levels of total CREB3L2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CREB3L2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CREB3L2

Target: CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))

Alternative Name: CREB3L2 (CREB3L2 Products)

Synonyms: CREB3L2 antibody, bbf2h7 antibody, BBF2H7 antibody, C530025K05Rik antibody, Ra69 antibody, SCIRR69 antibody, zgc:158603 antibody, cAMP responsive element binding protein 3 like 2 antibody, cAMP responsive element binding protein 3-like 2 antibody, cAMP responsive element binding protein 3-like 2 L homeolog antibody, CREB3L2 antibody, creb3l2 antibody, Creb3l2 antibody, creb3l2.L antibody

Background:

Description: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).

Gene: CREB3L2

Molecular Weight: 58 kDa

Gene ID: 64764

UniProt: Q70SY1

Pathways: Thyroid Hormone Synthesis