Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody

Details for Product No. ABIN183134
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Antigen
Synonyms vdac1, VDAC1, 5076, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, ATVDAC1, T22N4.9, T22N4_9, voltage dependent anion channel 1, PORIN, VDAC-1, AL033343, Vdac5, fa13f11, wu:fa13f11, zgc:85830
Epitope
C-Term
(36), (17), (12), (11), (6), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Sheep (Ovine), Zebrafish (Danio rerio)
(131), (51), (51), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(88), (47)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(122), (61), (43), (39), (24), (21), (10), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μg
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Immunogen Synthetic peptide directed towards the C terminal of human VDAC1
Sequence SAKVNNSSLI GLGYTQTLKP GIKLTLSALL DGKNVNAGGH KLGLGLEFQA
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 100 %, African clawed frog : 90 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against VDAC1. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name VDAC1 (VDAC1 Antibody Abstract)
Background The voltage-dependent anion-selective channel 1 (VDAC1) functions as a channel in membranous structures for the outer mitochondrial membrane, the cell membrane, endosomes, caveolae, the sarcoplasmatic reticulum, synaptosomes, and post-synaptic density fraction. A major function of VDAC1 in the plasma membrane is that of a NADH(-ferricyanide) reductase that may be involved in the maintenance of cellular redox homeostasis.
Molecular Weight 31 kDa
Gene ID 7416
NCBI Accession NP_003365, NM_003374
UniProt Q5FVE7
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 283 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody WB Suggested Anti-VDAC1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1...
anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody (2) anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody (Image 2)
anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody (3) WB Suggested Anti-VDAC1
Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500 <...
Product cited in: Rousset, Nguyen, Grange et al.: "Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes." in: PLoS ONE, Vol. 8, Issue 6, pp. e66478, 2013 (PubMed).

Arduíno, Esteves, Cortes et al.: "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic." in: Human molecular genetics, Vol. 21, Issue 21, pp. 4680-702, 2012 (PubMed).

Chen, Martin, Maya-Mendoza et al.: "Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins." in: Journal of proteome research, Vol. 8, Issue 11, pp. 5196-211, 2009 (PubMed).

Background publications Zheng, Shi, Tian et al.: "Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide." in: Oncogene, Vol. 23, Issue 6, pp. 1239-47, 2004 (PubMed).

Validation Images
Catalog No. ABIN183134
229.00 $
Plus shipping costs $45.00
Quantity
Price
100 μg
229.00 $

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