Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody

Details for Product No. ABIN183134
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Antigen
Synonyms vdac1, VDAC1, 5076, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, ATVDAC1, T22N4.9, T22N4_9, voltage dependent anion channel 1, PORIN, VDAC-1, AL033343, Vdac5, fa13f11, wu:fa13f11, zgc:85830
Epitope
C-Term
(37), (7), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Dog (Canine), Guinea Pig, Cow (Bovine), Zebrafish (Danio rerio), Human, Horse (Equine), Sheep (Ovine)
(87), (37), (36), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(46), (45)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(91), (49), (38), (27), (14), (4), (2), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN183134
229.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human VDAC1
Sequence SAKVNNSSLI GLGYTQTLKP GIKLTLSALL DGKNVNAGGH KLGLGLEFQA
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 100 %, African clawed frog : 90 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against VDAC1. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name VDAC1
Background The voltage-dependent anion-selective channel 1 (VDAC1) functions as a channel in membranous structures for the outer mitochondrial membrane, the cell membrane, endosomes, caveolae, the sarcoplasmatic reticulum, synaptosomes, and post-synaptic density fraction. A major function of VDAC1 in the plasma membrane is that of a NADH(-ferricyanide) reductase that may be involved in the maintenance of cellular redox homeostasis.
Molecular Weight 31 kDa
Gene ID 7416
NCBI Accession NP_003365, NM_003374
UniProt Q5FVE7
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 283 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody WB Suggested Anti-VDAC1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody (2) anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody (Image 2)
anti-Voltage-Dependent Anion Channel 1 (VDAC1) (C-Term) antibody (3) WB Suggested Anti-VDAC1
Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
VDAC1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells
Background publications Zheng, Shi, Tian et al.: "Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide." in: Oncogene, Vol. 23, Issue 6, pp. 1239-47, 2004 (PubMed).

Validation Images
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