ASIC3 antibody (N-Term)

Catalog No. ABIN183138

The Rabbit Polyclonal anti-ASIC3 antibody (ABIN183138) specifically detects ASIC3 in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit and Pig samples.

Quick Overview for ASIC3 antibody (N-Term) (ABIN183138)

Target: ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASIC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ASIC3 Antibody

Binding Specificity: N-Term

Sequence: VATFLYQVAE RVRYYREFHH QTALDERESH RLIFPAVTLC NINPLRRSRL

Predicted Reactivity: Cow: 80%, Dog: 80%, Guinea Pig: 80%, Horse: 80%, Human: 100%, Mouse: 87%, Pig: 87%, Rabbit: 87%, Rat: 87%

Characteristics: This is a rabbit polyclonal antibody against ACCN3. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ACCN3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 531 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ASIC3

Target: ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))

Alternative Name: ACCN3

Background: ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
Alias Symbols: ACCN3, TNaC1, DRASIC, SLNAC1
Protein Interaction Partner: ASIC3, LIN7B, GOPC, INADL, DLG4, MAGI1, ASIC2, STOM, CSNK2A1, PRKACA, STOML1,
Protein Size: 531

Molecular Weight: 58 kDa

Gene ID: 9311

NCBI Accession: NM_004769, NP_004760

UniProt: Q9UHC3