Amiloride-Sensitive Cation Channel 3 (ACCN3) (N-Term) antibody

Details for Product No. ABIN183138
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Antigen
Synonyms ACCN3, Accn3, DRASIC, SLNAC1, TNaC1, AW742291, TNAC1
Epitope
N-Term
(12), (9), (2), (2), (2), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
(35), (25), (18), (17)
Host
Rabbit
(37), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(24), (15), (11), (10), (9), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN183138
229.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human ACCN3
Sequence VATFLYQVAE RVRYYREFHH QTALDERESH RLIFPAVTLC NINPLRRSRL
Predicted Reactivity Human : 100 %, Mouse : 80 %, Rabbit : 80 %, Rat : 80 %, Bovine : 80 %, Dog : 80 %, Guinea pig : 80 %, Horse : 80 %
Characteristics This is a rabbit polyclonal antibody against ACCN3. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name ACCN3
Background ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
Molecular Weight 58 kDa
Gene ID 9311
NCBI Accession NP_004760, NM_004769
UniProt Q9UHC3
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 531 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (N-Term) antibody anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (N-Term) antibody
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (N-Term) antibody (2) WB Suggested Anti-ACCN3
Antibody Titration: 2.5 µg/mL ELISA Titer: 1:.2500
Positive Control: Human Kidney
Background publications Jones, Slater, Cadiou et al.: "Acid-induced pain and its modulation in humans." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 48, pp. 10974-9, 2004 (PubMed).

Validation Images
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