JMJD2D antibody (C-Term)

Catalog No. ABIN183251

There are 2+ publications for this product available. The Rabbit Polyclonal anti-JMJD2D antibody is suitable to detect JMJD2D in samples from Human. It has been validated for WB.

Quick Overview for JMJD2D antibody (C-Term) (ABIN183251)

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD2D antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-JMJD2D Antibody

Binding Specificity: C-Term

Purpose: JMJD2D Antibody - C-terminal region

Sequence: SSTPGPSAQI IHPSNGRRGR GRPPQKLRAQ ELTLQTPAKR PLLAGTTCTA

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against JMJD2D. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human JMJD2D

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104665

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-JMJD2D antibody (ABIN183251)

Kim, Fuchs, Schwartz, Abdelhamid, Etter, Berry, Li, Ihnat, Li, Janknecht: "Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors." in: American journal of translational research, Vol. 6, Issue 3, pp. 236-47, (2014) (PubMed).

Kim, Oh, Shin, Janknecht: "Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D." in: PLoS ONE, Vol. 7, Issue 4, pp. e34618, (2012) (PubMed).

Target Details for JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Alternative Name: JMJD2D

Background:

Background Information: JMJD2D belongs to JMJD2 family that is consist of four cancer-associated genes

Gene Name: Lysine (K)-specific demethylase 4D

Alternative Symbols: JMJD2D

Protein Name: Lysine-specific demethylase 4D

Molecular Weight: 59kDa

Gene ID: 55693

NCBI Accession: NP_060509

UniProt: Q6B0I6

Pathways: Warburg Effect