JMJD2D antibody (AA 400-480)

Catalog No. ABIN7229270

This Rabbit Polyclonal antibody specifically detects JMJD2D in ELISA and WB. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for JMJD2D antibody (AA 400-480) (ABIN7229270)

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD2D antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-JMJD2D Antibody

Binding Specificity: AA 400-480

Purpose: Rabbit Anti-KDM4D Polyclonal Antibody

Specificity: The antibody detects endogenous levels of KDM4D protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human KDM4D protein at AA range: 400-480

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Alternative Name: KDM4D

Background: Lysine-specific demethylase 4D, JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2DKDM4D (Lysine Demethylase 4D) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include dioxygenase activity and histone demethylase activity (H3-K9 specific). An important paralog of this gene is KDM4F. Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor H4 Lys-20. Demethylates both di- and trimethylated H3 Lys-9 residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Molecular Weight: 57kD

Gene ID: 55693

UniProt: Q6B0I6

Pathways: Warburg Effect