Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (Middle Region) antibody

Details for Product No. ABIN184019
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Antigen
Synonyms CPSF6, wu:fa22f12, zgc:85819, 4733401N12Rik, AI256641, CFIM, CFIM68, HPBRII-4, HPBRII-7
Epitope
Middle Region
(9), (9), (8), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Pig (Porcine), Zebrafish (Danio rerio), Human, Chicken
(30), (6), (4), (1)
Host
Rabbit
(18), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(29), (18), (5), (5), (3), (3)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN184019
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Immunogen Synthetic peptide directed towards the middle region of human CPSF6
Sequence PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV PGYGPPPGPP
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against CPSF6. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name CPSF6
Background CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides.The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.
Molecular Weight 61 kDa
Gene ID 11052
NCBI Accession NP_008938, NM_007007
UniProt Q16630
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 551 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (Middle Region) antibody WB Suggested Anti-CPSF6 Antibody Titration: 0.3125ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (Middle Region) antibody (2) anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (Middle Region) antibody (Image 2)
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (Middle Region) antibody (3) Sample Type: SKOV3
Primary Antibody Dilution: 4 µg/mL
Secondary Antibody: Anti-rabbit Alexa 546
Secondary Antibody Dilution: µg/mL
Gene Name: CPSF6
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (Middle Region) antibody (4) WB Suggested Anti-CPSF6
Antibody Titration: 0.3125 µg/mL ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate
CPSF6 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Validation Images
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