TIAL1 antibody (C-Term)

Catalog No. ABIN184155

This anti-TIAL1 antibody is a Rabbit Polyclonal antibody detecting TIAL1 in WB. Suitable for Human, Mouse, Rat, Dog, Rabbit, Zebrafish (Danio rerio), Cow, Guinea Pig and Horse.

Quick Overview for TIAL1 antibody (C-Term) (ABIN184155)

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIAL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TIAL1 Antibody

Binding Specificity: C-Term

Sequence: WNQQGFGVDQ SPSAAWMGGF GAQPPQGQAP PPVIPPPNQA GYGMASYQTQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 85%, Zebrafish: 76%

Characteristics: This is a rabbit polyclonal antibody against TIAL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TIAL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 375 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TIAL1

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Alternative Name: TIAL1

Background: The protein encoded by TIAL1 is a member of a family of RNA-binding proteins and possesses nucleolytic activity against cytotoxic lymphocyte target cells. The gene product is a cytotoxic granule-associated protein and has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. It has been suggested that members of this protein family may be involved in the induction of apoptosis. One isoform contains a lysosome-targeting motif in its C-terminal auxiliary domain, however, alternative splicing results in a T-cluster DNA-binding isoform, differing at the C-terminus where a hydrophobic sequence replaces the lysosome-targeting motif.
Alias Symbols: TCBP, TIAR
Protein Interaction Partner: SUMO2, UBC, RPA3, RPA2, RPA1, BMI1, SOX2, MAPK1, GADD45A, VCAM1, ITGA4, FN1, MRPL53, SARNP, UFM1, SBDS, MRPS28, TOMM40, ACAA2, GNB2L1, SF3B4, SCAMP3, SCO2, ALDH5A1, VDAC1, UBE2D2, THY1, SOD1, MBNL1, CAND1, DCUN1D1, COPS5, COPS6, CUL1, CUL2, CUL3, CUL4A, C
Protein Size: 375

Molecular Weight: 42 kDa

Gene ID: 7073

NCBI Accession: NM_003252, NP_003243

UniProt: Q01085