Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3) (C-Term) antibody

Details for Product No. ABIN184283
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Antigen
Synonyms CG6755, Dmel\\CG6755, Elo-A, dEloA, tceb3a, zgc:56638, wu:fw66g10, TCEB3, 110kDa, AA408125, Tceb3a, El, EloA, SIII, SIII p110, TCEB3A
Epitope
C-Term
(12), (8), (7), (6), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Chicken
(57), (18), (17), (12), (12)
Host
Rabbit
(48), (7), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(45), (22), (10), (8), (7), (6), (5), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN184283
229.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human TCEB3
Sequence AYDGPSTSSA HLAPVVSSTV SYDPRKPTVK KIAPMMAKTI KAFKNRFSRR
Cross-Reactivity Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
Predicted Reactivity Dog : 100 %, Chicken : 90 %, Rat : 90 %, Guinea pig : 90 %
Purification Protein A purified
Alternative Name TCEB3
Background Elongin A (TCEB3), which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits.This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Molecular Weight 87 kDa
NCBI Accession NM_003198, NP_003189
UniProt Q14241
Application Notes WB Suggested Anti-TCEB3 Antibody Titration: 7.5 µg/mL
Positive Control: Transfected 293T.
Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 772 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C
Storage Comment Any unfrozen and/or unused material can be stored at 4 °C for short term use (< 1 week), and should not be re-frozen. For longer periods of storage, store at -24 °C
Supplier Images
anti-Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3) (C-Term) antibody WB Suggested Anti-TCEB3 Antibody Titration: 7.5ug/ml
Positive Control: Transfected 293T
anti-Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3) (C-Term) antibody (2) anti-Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3) (C-Term) antibody (Image 2)
Background publications Beausoleil, Jedrychowski, Schwartz et al.: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).

Validation Images
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