PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1) antibody

Antigen: PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1)

Synonyms: PINX1, LPTL, LPTS, MGC8850, FLJ20565, RGD1566025, MGC127183

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN184695

Additional Information

Alternative name: PINX1

Gene ID: 54984

Immunogen: SMLAERRRKQKWAV-C

Format: Affinity-purified

Description: All names and symbols: PINX1, PIN2-interacting protein 1, LPTS, MGC8850, FLJ20565, LPTL, 67-11-3 protein, hepatocellular carcinoma-related putative tumor suppressor. Official Symbol: PINX1. RefSeq number(s): NP_060354.4. Gene ontology terms: nucleic acid binding, molecular_function unknown, negative regulation of cell proliferation, telomerase-dependent telomere maintenance, nucleus, cellular_component unknown, negative regulation of cell cycle, chromosome, telomeric region

Specificity: Human, Mouse 328 aa

Application Details

Application Notes: Western blot: Approx 35kDa band seen in Jurkat lysate. Recommended for use at 1-3µg/ml.

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Buffer: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Storage: Aliquot and store at -20°C. Minimize freezing and thawing.

Research Area: Chromatin and Nuclear Signaling, DNA/RNA

Restrictions: For Research Use only

Images

ABIN184695 staining (2µg/ml) of Jurkat lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Publications

Publications: Zhou, Lu: "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor." in: Cell, Vol. 107, Issue 3, pp. 347-59, 2001 (PubMed).