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CAMP Responsive Element Modulator (CREM) antibody
| Antigen | CAMP Responsive Element Modulator (CREM) |
| Synonyms | ICER, hCREM-2, MGC17881, MGC41893, MGC111110, Icer, CREM, MGC127769, MGC140070 |
| Clonality | Polyclonal |
| Host |
 Alternatives Goat |
| Reactivity |
Alternatives Human |
| Application |
Alternatives ELISA, Western Blotting (WB)
|
 |
1 reference available |
| Catalog no. | ABIN185300 |
| Quantity | 100 ug |
| Price | 501.80 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 Business Days |
Additional Information
| Alternative name | CREM |
| Gene ID | 1390 |
| Immunogen | LETLKDICSPKTDY |
| Format | Affinity-purified |
| Description | All names and symbols: CREM, ICER, MGC17881, MGC41893, MGC111110, hCREM-2, cAMP responsive element modulator, hCREM 2alpha-b protein, hCREM 2beta-a protein, inducible cAMP early repressor ICER. Official Symbol: CREM. RefSeq number(s): NP_853549.1, NP_874387.1, NP_874388.1, NP_874393.1, NP_874394.1, NP_877570.1, NP_877571.1, NP_877572.1, NP_877573.1, NP_878270.1, NP_898883.1. Gene ontology terms: DNA binding, cAMP response element binding protein binding, nucleus, nucleus, nucleus, protein binding, regulation of transcription, DNA-dependent, regulation of transcription, DNA-dependent, signal transduction, transcription factor activity |
| Specificity | This antibody is expected to recognise the following protein isoforms of human CREM protein: a (NP_853549.1), e (NP_874387.1), f (NP_874388.1), k (NP_874393.1), l (NP_874394.1), m (NP_877570.1), n (NP_877571.1), o (NP_877572.1), p (NP_877573.1), q (NP_878270.1), v (NP_898883.1). This antibody is not expected to cross-react with CREB protein. Human, Mouse, Rat 300, 109 aa, 121 aa, 113 aa, 121 aa, 245 aa, 182 aa, 270 aa, 207 aa, 96 aa, 221 aa |
Application Details
| Application Notes | Peptide ELISA: antibody detection limit dilution 1:16,000. Western Blot: Approx 30kDa band observed in human heart lysates (calculated MW of 32.5kDa according to NP_853549.1). Recommended concentration: 1-3µg/ml. |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Research Area | Signaling |
| Restrictions | For Research Use only |
Images
| ABIN185300 staining (1µg/ml) of human heart lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. |
Publications
| Publications |
Tenbrock, Juang, Tolnay et al.: "The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 6, pp. 2971-6, 2003 (PubMed).
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Alternatives
Alternatives for antigen "CAMP Responsive Element Modulator (CREM)", type "Antibodies"
| Hosts | Rabbit (24), Mouse (5), Goat (2), Sheep (1) |
| Reactivities | Human (28), Mouse (Murine) (20), Rat (Rattus) (20), Cow (Bovine) (4), Rabbit (4), Horse (Equine) (3), Dog (Canine) (2), Pig (Porcine) (2), Chicken (1) |
| Applications | Flow Cytometry (FACS) (18), Immunofluorescence (IF) (18), Western Blotting (WB) (14), ELISA (6), Enzyme Immunoassay (EIA) (3), ELISA (Detection) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (IHC) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1) |
| Conjugates | Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1) |
| Epitopes | pS271 (2) |
