CREM antibody (AA 251-361)

Catalog No. ABIN755362

This Rabbit Polyclonal antibody specifically detects CREM in IF (cc), IF (p), FACS, IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for CREM antibody (AA 251-361) (ABIN755362)

Target: CREM (CAMP Responsive Element Modulator (CREM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREM antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CREM Antibody

Binding Specificity: AA 251-361

Purpose: CREM Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CREM

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CREM

Target: CREM (CAMP Responsive Element Modulator (CREM))

Alternative Name: CREM

Background:

Synonyms: cAMP response element modulator, CREM-1, cAMP responsive element modulator, hCREM 2, hCREM2, ICER, Inducible cAMP early repressor, Inducible cAMP early repressor ICER, MGC111110, MGC17881, MGC41893.

Background: CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.

Gene ID: 1390

UniProt: Q03060

Pathways: Retinoic Acid Receptor Signaling Pathway