ADAM Metallopeptidase Domain 17 (ADAM17) (C-Term) antibody

Antigen: ADAM Metallopeptidase Domain 17 (ADAM17)

Synonyms: CSVP, TACE, ADAM18, CD156B, MGC71942, Tace, CD156b, ADAM17, adam17, si:dkey-81b15.2

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN187860

Additional Information

Alternative name: CD156b / ADAM17 (C-term)

Immunogen: Synthetic peptide corresponding to amino acids 807 to 823 of the human TACE protein. Immunogen sequence differs from the mouse and rat sequences by one amino acid.

Description: Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-alpha is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-alpha. TNF-alpha converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintergrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.

Specificity: Detects TACE by Western blot at 0.25 to 1 µg/ml. Detects an approximately 130 kDa band in HeLa and Jurkat whole cell lysate which may represent mature protein, precursor, and glycosylated TACE. Species Reactivity: Human, other species not tested. Positive Control: HeLa and Jurkat whole cell lysates.

Application Details

Application Notes: Western blot The optimal dilution for a specific application should be determined by the researcher.

Buffer: Purified antibody provided in PBS solution containing 0.02% sodium azide.

Storage: Store at 4-8 °C. Do NOT freeze.

Restrictions: For Research Use only