CREB3 antibody (N-Term)

Catalog No. ABIN1881228

Product Details anti-CREB3 Antibody

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Binding Specificity: AA 66-94, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CREB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CREB3.

Clone: RB42213

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CREB3 antibody (ABIN1881228)

Kim, Choi, Choi, Kang, Kim, Lee, Lee, Lee, Kim, Jun, Jeong, Yoon: "HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 20, pp. 3499-510, (2010) (PubMed).

Audas, Li, Liang, Lu: "A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 3952-66, (2008) (PubMed).

Target Details for CREB3

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Alternative Name: CREB3 (CREB3 Products)

Synonyms: LUMAN antibody, LZIP antibody, AU044960 antibody, AW538053 antibody, C80076 antibody, LZIP-1 antibody, LZIP-2 antibody, Luman antibody, creb3 antibody, luman antibody, lzip antibody, cAMP responsive element binding protein 3 antibody, cAMP responsive element binding protein 3 S homeolog antibody, CREB3 antibody, Creb3 antibody, creb3.S antibody

Background: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

Molecular Weight: 41379

NCBI Accession: NP_006359

UniProt: O43889

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response