DUSP10 antibody (AA 204-232)

Catalog No. ABIN1881272

Product Details anti-DUSP10 Antibody

Target: DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

Binding Specificity: AA 204-232

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP10 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DUSP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the Central region of human DUSP10.

Clone: RB41917

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DUSP10 antibody (ABIN1881272)

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Tephly, Carter: "Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 1, pp. 113-23, (2008) (PubMed).

Teng, Huang, Meng: "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress." in: The Journal of biological chemistry, Vol. 282, Issue 39, pp. 28395-407, (2007) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for DUSP10

Target: DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

Alternative Name: DUSP10 (DUSP10 Products)

Synonyms: DUSP10 antibody, MKP-5 antibody, MKP5 antibody, 2610306G15Rik antibody, AI158871 antibody, Mkp-5 antibody, Mkp5 antibody, dual specificity phosphatase 10 antibody, DUSP10 antibody, Dusp10 antibody

Background: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique, it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Molecular Weight: 52642

NCBI Accession: NP_009138, NP_653329, NP_653330

UniProt: Q9Y6W6