LGALS3BP antibody (AA 383-412)

Catalog No. ABIN1881492

Product Details anti-LGALS3BP Antibody

Target: LGALS3BP (Lectin, Galactoside-Binding, Soluble, 3 Binding Protein (LGALS3BP))

Binding Specificity: AA 383-412

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGALS3BP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LGALS3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the Central region of human LGALS3BP.

Clone: RB40516

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000. IHC-P-Leica: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LGALS3BP antibody (ABIN1881492)

Srirajaskanthan, Caplin, Waugh, Watkins, Meyer, Hsuan, Beaumont: "Identification of Mac-2-binding protein as a putative marker of neuroendocrine tumors from the analysis of cell line secretomes." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 4, pp. 656-66, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Zambelli, Zuntini, Nardi, Manara, Serra, Landuzzi, Lollini, Ferrari, Alberghini, Llombart-Bosch, Piccolo, Iacobelli, Picci, Scotlandi: "Biological indicators of prognosis in Ewing's sarcoma: an emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP)." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 1, pp. 41-52, (2009) (PubMed).

Lee, Zhang, Shin, Lee, Kim: "Mac-2 binding protein and galectin-3 expression in mucinous tumours of the ovary: an annealing control primer system and immunohistochemical study." in: Pathology, Vol. 41, Issue 3, pp. 229-33, (2009) (PubMed).

Kim, Lee, Sung, Choi, Choi, Kim, Kim, Yu, Hwang, Kim: "Increased serum 90K and Galectin-3 expression are associated with advanced stage and a worse prognosis in diffuse large B-cell lymphomas." in: Acta haematologica, Vol. 120, Issue 4, pp. 211-6, (2009) (PubMed).

Target Details for LGALS3BP

Target: LGALS3BP (Lectin, Galactoside-Binding, Soluble, 3 Binding Protein (LGALS3BP))

Alternative Name: LGALS3BP (LGALS3BP Products)

Synonyms: 90K antibody, BTBD17B antibody, MAC-2-BP antibody, TANGO10B antibody, Ppicap antibody, CyCAP antibody, MAC-2BP antibody, Tango10b antibody, lgals3bp antibody, zgc:136780 antibody, MAC2BP antibody, Mac-2 BP antibody, zgc:77059 antibody, galectin 3 binding protein antibody, lectin, galactoside-binding, soluble, 3 binding protein antibody, calcium activated nucleotidase 1 antibody, lectin, galactoside-binding, soluble, 3 binding protein a antibody, lectin, galactoside-binding, soluble, 3 binding protein b antibody, LGALS3BP antibody, Lgals3bp antibody, CANT1 antibody, lgals3bpa antibody, lgals3bpb antibody

Background: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.

NCBI Accession: NP_005558

UniProt: Q08380