TIAM1 antibody (C-Term)

Catalog No. ABIN1881884

There are 3+ publications for this product available. The Rabbit Polyclonal anti-TIAM1 antibody is suitable to detect TIAM1 in samples from Human. It has been validated for WB.

Quick Overview for TIAM1 antibody (C-Term) (ABIN1881884)

Target: TIAM1 (T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIAM1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41848

Product Details anti-TIAM1 Antibody

Binding Specificity: AA 1478-1506, C-Term

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TIAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1478-1506 amino acids from the C-terminal region of human TIAM1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TIAM1 antibody (ABIN1881884)

Yang, Lv, Liu, Liu, Yang, Hu: "Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma." in: Japanese journal of clinical oncology, Vol. 40, Issue 11, pp. 1053-9, (2010) (PubMed).

Moriarty, Pursell, Mercurio: "miR-10b targets Tiam1: implications for Rac activation and carcinoma migration." in: The Journal of biological chemistry, Vol. 285, Issue 27, pp. 20541-6, (2010) (PubMed).

Shepherd, Klaus, Liu, Ramaswamy, DeMali, Fuentes: "The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion." in: Journal of molecular biology, Vol. 398, Issue 5, pp. 730-46, (2010) (PubMed).

Target Details for TIAM1

Target: TIAM1 (T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1))

Alternative Name: TIAM1

Background: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.

Molecular Weight: 177508

NCBI Accession: NP_003244

UniProt: Q13009