ZBTB7B antibody (C-Term)

Catalog No. ABIN1882155

Product Details anti-ZBTB7B Antibody

Target: ZBTB7B (Zinc Finger and BTB Domain Containing 7B (ZBTB7B))

Binding Specificity: AA 440-469, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB7B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-469 amino acids from the C-terminal region of human ZBTB7B.

Clone: RB13260

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ZBTB7B antibody (ABIN1882155)

Matsumoto, Nagoshi, Yoshida, Kato, Kuroda, Shimura, Kaneko, Horiike, Nakamura, Taniwaki: "Expression of Master Regulators of T-cell, Helper T-cell and Follicular Helper T-cell Differentiation in Angioimmunoblastic T-cell Lymphoma." in: Internal medicine (Tokyo, Japan), Vol. 56, Issue 21, pp. 2851-2856, (2018) (PubMed).

Matsumoto, Horiike, Ohshiro, Yamamoto, Sasaki, Tsutsumi, Kobayashi, Shimizu, Uchiyama, Kuroda, Nomura, Shimazaki, Taniwaki: "Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma, not otherwise specified, by immunohistochemical analysis." in: American journal of clinical pathology, Vol. 133, Issue 2, pp. 281-90, (2010) (PubMed).

Galéra, Musso, Ducy, Karsenty: "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 20, pp. 9372-6, (1994) (PubMed).

Target Details for ZBTB7B

Target: ZBTB7B (Zinc Finger and BTB Domain Containing 7B (ZBTB7B))

Alternative Name: ZBTB7B (ZBTB7B Products)

Synonyms: THPOK antibody, ZBTB15 antibody, ZFP-67 antibody, ZFP67 antibody, ZNF857B antibody, c-KROX antibody, hcKROX antibody, Thpok antibody, Zfp67 antibody, c-Krox antibody, ZBTB7B antibody, zbtb7b antibody, MGC130914 antibody, zinc finger and BTB domain containing 7B antibody, kruppel-related zinc finger protein hcKrox antibody, ZBTB7B antibody, Zbtb7b antibody, zbtb7b antibody

Background: ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

Molecular Weight: 58027

NCBI Accession: NP_001239335, NP_001243384

UniProt: O15156