CASP14 antibody (C-Term)

Catalog No. ABIN1887094

Product Details anti-CASP14 Antibody

Target: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASP14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide from near the carboxy terminus of human caspase-14.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CASP14

Target: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Alternative Name: Caspase-14 (CASP14 Products)

Synonyms: CASP14 antibody, MICE antibody, mini-ICE antibody, caspase 14, apoptosis-related cysteine peptidase antibody, caspase 14 antibody, caspase-14-like antibody, caspase-14 antibody, CASP14 antibody, Casp14 antibody, LOC485601 antibody, LOC780455 antibody

Background: Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies.Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18.Caspase-14 is highly expressed in embryonic but not adult tissues.It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo.The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Synonyms: Mini-interleukin-1 converting enzyme, Mini-ICE, MICE

NCBI Accession: NP_033939