2B4 antibody (C-Term)

Catalog No. ABIN1887149

Product Details anti-2B4 Antibody

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 2B4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): At least three isoforms of SLAMF4 are known to exist. SLAMF4 antibody is predicted to not cross-react with other SLAM protein family members.

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the carboxy terminus of human SLAMF4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for 2B4

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Alternative Name: SLAMF4 (CD244 Products)

Synonyms: CD244 antibody, 2B4 antibody, NAIL antibody, NKR2B4 antibody, Nmrk antibody, SLAMF4 antibody, C9.1 antibody, F730046O15Rik antibody, Ly90 antibody, CD244 molecule antibody, CD244 natural killer cell receptor 2B4 antibody, CD244 antibody, Cd244 antibody

Background: The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation.It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells.Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.
Synonyms: Signaling lymphocytic activation molecule family member 4, natural killer cell receptor 2B4, NKR2B4, 2B4, NAIL, NMRK, CD244

NCBI Accession: NP_1160135