DR4 antibody (C-Term)

Catalog No. ABIN1887404

Product Details anti-DR4 Antibody

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for DR4

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Alternative Name: DR4 (DR4 Products)

Synonyms: APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNF receptor superfamily member 10a antibody, TNFRSF10A antibody

Background: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms.Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas.A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4).The ligand for this novel death receptor has been identified and termed TRAIL2, 3, which is a new member in the TNF family.DR4 is also called TRAIL receptor-1 (TRAIL-R1).DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus.Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappaB activation in many tissues and cells.
Synonyms: TRAIL-R1

Molecular Weight: 57 kDa

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity