MED28 antibody (Center)

Catalog No. ABIN1887640

Product Details anti-MED28 Antibody

Target: MED28 (Mediator Complex Subunit 28 (MED28))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED28 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide from near the center of human MED28.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for MED28

Target: MED28 (Mediator Complex Subunit 28 (MED28))

Alternative Name: MED28 (MED28 Products)

Synonyms: 1500003D12Rik antibody, EG1 antibody, magicin antibody, Eg1 antibody, FKSG20 antibody, RGD1305875 antibody, wu:fc74b11 antibody, zgc:103633 antibody, AI451633 antibody, AU045690 antibody, mediator complex subunit 28 antibody, MED28 antibody, Med28 antibody, med28 antibody

Background: The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor.One of the proteins in this complex is MED28, also known as Magicin.MED28 is expressed in many cell lines and tissues.It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes.MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin's tumor suppressive activity.MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment.At least two isoforms of MED28 are known to exist.
Synonyms: Mediator of RNA polymerase II transcription subunit 28, magicin, EG1

NCBI Accession: NP_079481

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation