ARHGEF17 antibody (Center)

Catalog No. ABIN1887696

Product Details anti-ARHGEF17 Antibody

Target: ARHGEF17 (rho Guanine Nucleotide Exchange Factor (GEF) 17 (ARHGEF17))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF17 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the center of human TEM4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for ARHGEF17

Target: ARHGEF17 (rho Guanine Nucleotide Exchange Factor (GEF) 17 (ARHGEF17))

Alternative Name: TEM4 (ARHGEF17 Products)

Synonyms: P164RHOGEF antibody, TEM4 antibody, p164-RhoGEF antibody, 8030463K16 antibody, AI428794 antibody, AW558066 antibody, BC035332 antibody, mKIAA0337 antibody, Rho guanine nucleotide exchange factor 17 antibody, Rho guanine nucleotide exchange factor (GEF) 17 antibody, ARHGEF17 antibody, Arhgef17 antibody

Background: Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions.TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain.TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart.It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation.Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues.TEM4 could also prove to be useful targets therapeutically.
Synonyms: Tumor endothelial marker 4, ARHGEF17, Rho guanine nucleotide exchange factor 17, p164RHOGEF

UniProt: Q96PE2