Natriuretic peptides B (NT-proBNP (AA 1-21) antibody

Antigen: Natriuretic peptides B (NT-proBNP

Epitope: AA 1-21

Clonality: Monoclonal (1.11.7)

Host: Mouse

Reactivity: Human

Application: Enzyme Immunoassay (EIA)

Catalog no.: ABIN191901

Additional Information

Characteristics: Synonyms: NPPB, Brain natriuretic peptide, BNP, proBNP, Gamma-brain natriuretic peptide

Swiss-Prot: P16860

Immunogen: Synthetic human pro-BNP (aa 1-21) poly Lysin conjugatedAA Sequence: HPLGSPGSASDLETSGLQEQR

Cross-Reactivity: Human

Isotype: IgG2a  (Matching secondary antibodies)

Clone: 1.11.7

Description: In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor(prepro-BNP), which is cleaved by proteases to form a 26 aa signal peptide and a 108 aapro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminalNT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP andNTproBNP circulate in human plasma and have been proposed as markers for earlydiagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiaccomplications at patients with heart failure.

Specificity: This antibody detects synthetic pro-Brain Natriuretic Peptide (aa 1-21). Species: Human. Others not tested. Add. Information: LocusID 4879

Application Details

Application Notes: ELISA. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Purified

Buffer: 200 mM Na Citrat / TRIS, 500 mM NaCl buffer pH 7,5 0,02 % NaN3Reconstitution: Restore in aqua bidest to 1 mg/ml

Storage: Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing. Shelf life: One year from despatch.

Research Area: Hormones

Restrictions: For Research Use only