CD36 Molecule (thrombospondin Receptor) (CD36) antibody (PE)

Antigen: CD36 Molecule (thrombospondin Receptor) (CD36)

Synonyms: FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3

Clonality: Monoclonal (TR9)

Host: Mouse

Reactivity: Human

Conjugate: PE

Application: Flow Cytometry (FACS)

Catalog no.: ABIN192350

Additional Information

Alternative name: CD36

Immunogen: Platelets

Isotype: IgG1

Clone: TR9

Description: CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs tothe class B family of scavenger receptors. CD36 is expressed by most resting marginal zoneB cells but not by follicular and B1 B cells, and it is rapidly induced on Follicular B cells invitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, butmodulates both primary and secondary antibody response. Similarly to glucose transporterGLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cellstimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chainfatty acids.

Specificity: The antibody TR9 reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoproteinexpressed on platelets, macrophages, endothelial cells, early erythroid cells andmegakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibodyOKM5.Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes totarget cells).

Application Details

Application Notes: The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

Storage: Store in the dark at 2-8 o C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Research Area: Cancer, Atherosclerosis, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only

Images

Surface staining of human platelets with anti-CD36 (TR9) FITC.